An innovative breath-collecting device developed by academics at Northumbria University could revolutionise the way we diagnose diseases, such as the newly-emerged strain of Coronavirus, COVID-19.
Northumbria University has secured regional support and funding for the next stage of product and business development of technology that enables diagnosis of disease through breath collection.
Research shows that our breath contains valuable biological information, also known as biomarkers, that can indicate health and disease.
Biomarkers such as DNA, RNA, proteins, and lipids found in the breath have diagnostic potential for diseases of the lung and beyond.
The new device works by sampling the lung in a non-invasive way – by patients breathing into it – in order to retrieve these biomarkers.
To date, systems that diagnose from breath sampling have not proven to be reliable enough due to contamination, sample loss and variability issues in breath analysis.
However, the new device resolves these issues so that the data collected through this pioneering invention closely resembles results from lung samples taken surgically.
It is hoped that in the future the technology could be used in the diagnosis of lung diseases as well as other health issues such as diabetes, cancers, liver problems, brain and ageing diseases.
Research and development of this technology was led by Dr Sterghios Moschos, an associate professor at Northumbria University while at Westminster University, and has been progressed further while at Northumbria.
He explains: “Our ambition is to reduce the need for bloodletting for diagnosis in its broadest sense.The team has ambitions for this technology to replace invasive venous and respiratory sampling tests where possible, particularly for older and younger patients where needles and invasive tests can be uncomfortable or sometimes not possible
“The research evidence that shows this is possible is well established, but what is missing is the standardised and reliable approach to do so outside the research lab: in pharmacies, GP surgeries or the back of an ambulance, for example.
“In the case of Coronavirus, temperature monitoring in airports is not sufficient.
“The World Health Organization currently recommends testing nasal swabs, oral swabs and swabs from inside the lungs to avoid missing the infection. That’s why it’s vital that we develop non-invasive, quick and cost-effective tests for diagnosis and screening.”
Development of the diagnostics platform has been greatly supported by funding from Northern Accelerator, which made it possible to bring together a team to create a functioning prototype of the device.
Northumbria graduate, Saqib Ali, has been appointed as a design engineer for the project and has carried out the rapid prototyping of the innovative device using 3D printers within the university’s engineering labs.
Dr Tim Hammond, project lead for the multi-university research commercialisation programme, the Northern Accelerator, said: “Dr Moschos’ technology is exactly the kind of project Northern Accelerator sets out to progress.
"Our pre-incorporation funding, along with a range of other support, helps academics turn their promising ideas and world-class research into real-world impact.
It is a pleasure working with such an ambitious team behind the breath sampling device and we look forward to working with them in future as they bring their platform to market
“This device does exactly that – with our support it’s developing from an idea to a prototype, to a business that will impact healthcare around the world, as well as increasing R&D expenditure and creating jobs here in the North East.”
The project has also been supported by North by Northwest partner’s, Innovation to the Commercialisation of University Research (ICURe) programme.
This support enabled the team to get out of the lab and speak to 144 key opinion leaders in breath diagnostics in the US and EU.
These conversations helped find a market for their technology and develop a plan to take the technology out of the university.
North by Northwest partners’ head of innovation, Dr Paul Donachy said “NxNW is a community of innovators, entrepreneurs and investors helping accelerate the commercialisation of university research in the North of England, Scotland and Ireland.
“The InnovateUK-funded programme is a vital resource in helping university teams validate their early-stage technology in the market.
“It is a pleasure working with such an ambitious team behind the breath sampling device and we look forward to working with them in future as they bring their platform to market.”
The primary interest for the diagnostics platform lies in human healthcare, but other opportunities exist in other industries such as veterinary medicine, biosecurity, agritech, and food processing.
We need new medical technologies that quickly and easily diagnose disease and monitor heath, and this device is one of those technologies
Professor George Marston, pro vice chancellor of research and innovation at Northumbria University, said: “The team has ambitions for this technology to replace invasive venous and respiratory sampling tests where possible, particularly for older and younger patients where needles and invasive tests can be uncomfortable or sometimes not possible.
“We need new medical technologies that quickly and easily diagnose disease and monitor heath, and this device is one of those technologies.
“Sterghios and his team, along with our fantastic partners, have the skills and experience to take this technology to market, resulting in huge impact on healthcare globally in the coming years.”
