Digital health startup, Lenus Health, launches ground-breaking study in partnership with NHS Greater Glasgow and Clyde to transform management of the chronic lung disease
Lenus Health and NHS Greater Glasgow and Clyde are working together on a world-first trial exploring the impact of machine learning on the treatment of COPD patients
A clinical investigation launched today will explore how insights from artificial intelligence (AI) can improve care and prevent emergency hospital admissions for people with chronic obstructive pulmonary disease (COPD).
The study will use machine learning in live point-of-care workflows to identify patients at highest risk of adverse events and support the pro-active delivery of guideline-based care.
COPD is a progressive and preventable disease that affects around 1.2 million people in the UK and is the second-most-common cause of emergency hospital admissions.
And the annual economic burden of COPD on the NHS is estimated as £1.9billion, with treatment following exacerbations of symptoms accounting for 70% of those costs.
Supported by a £1.2m NHS Artificial Intelligence in Health and Care Award, the ‘DYNAMIC-AI’ clinical investigation is a 12-month feasibility study now underway among COPD patients at NHS Greater Glasgow and Clyde (NHSGGC).
These have the potential to give us back time to focus on patient-clinician human interactions and allow us to optimise preventative management to improve patient outcomes and quality of life, rather than continue to firefight with unsustainable reactive unscheduled care
The project between Lenus Health and NHSGGC is the first to operationalise predictive AI in direct patient care of chronic conditions.
“This is an incredibly-exciting project and the first time we’re bringing together predictive AI insight for COPD into live clinical practice,” said Dr Chris Carlin, consultant respiratory physician at NHSGGC, who is leading the investigation.
“With the ageing population and rising prevalence and complexity of long-term conditions, clinicians are overwhelmed with data that they don’t have the capacity to review.
“We need to deploy assistive technologies to provide us with prioritised insights from patient data.
“These have the potential to give us back time to focus on patient-clinician human interactions and allows us to optimise preventative management to improve patient outcomes and quality of life, rather than continue to firefight with unsustainable reactive unscheduled care.”
Lenus Health’s team of data scientists and engineers have pioneered the development and training of four machine learning models to pro-actively identify patients with COPD who are at risk of adverse events and provide actionable insights to improve care quality.
The proprietary AI algorithms are UKCA marked and were trained using close to one million data points from historical electronic health records from a de-identified cohort of more than 55,000 patients with COPD resident in NHSGGC.
We believe this is the first time there will be AI-derived predictive scores used directly within the day-to-day clinical workflow in COPD care
Lenus Health uses more than 80 data points to support the delivery or risk scores, significantly more than in a traditional rule-based system, which are known to cause numerous false alarms, leading to clinicians experiencing alarm fatigue.
“Rule-based systems are static whereas machine learning is much more robust in the context of routine care,” explained Dr Carlin.
As part of the study, clinical care teams will be provided with actionable insights from the models to use in multi-disciplinary team (MDT) reviews.
By identifying high-risk patients, they can be offered pro-active, preventative care to avoid the COPD symptom flare ups that currently cause one in eight emergency hospital admissions.
“Up until now, AI models have been used retrospectively in cohorts in which we can provide predictions looking back,” said Dr Carlin.
“We believe this is the first time there will be AI-derived predictive scores used directly within the day-to-day clinical workflow in COPD care.
We are confident that the introduction of clinical decision support based on AI-generated insights is the intervention which can truly transform management of chronic conditions like COPD by enabling prioritised care optimisation and enhanced proactive self-management support
“One of the key things we hope this will tell us is which patients are at risk of adverse outcome so we can provide anticipatory care.
“This will help us transform to a preventative, predictive, and pro-active care model that improves outcomes for patients and relieves pressures on the care system.”
COPD disproportionately affects deprived populations and it is estimation that the prevalence in the most-deprived 10% of areas in the UK is almost double that of the least deprived 10%.
The project’s pioneering work on fairness provides a meaningful scientific contribution to identifying biases held in health data and ensuring models perform appropriately across age groups, gender, deprivation categories and ethnicity.
And, as a result, it has the potential to improve access to healthcare to people living in socio-economically disadvantaged areas.
“Fairness is important across everything we do in healthcare,” said Dr Carlin.
“A significant benefit of bringing in data-driven technology is that it has the potential to address equality and access issues across health and social care delivery.”
The technology also has the potential to be quickly scaled and the model can be retrained on new data to predict other long-term conditions such as heart failure or for patients with more than one long-term condition.
We anticipate that the data science approach, technology infrastructure, and wider learnings from this exemplar study will accelerate the application of AI across other long-term conditions to help address growing demands on health systems caused by increasing levels of multi-morbidity
Lenus Health chief executive, Paul McGinness, said: “This trial is the culmination of many years work training and testing models, developing the technical infrastructure on Azure to automate generation of model risk scores, and establishing processes and explainability features with the clinical team to act on the insights provided.
“We are confident that the introduction of clinical decision support based on AI-generated insights is the intervention which can truly transform management of chronic conditions like COPD by enabling prioritised care optimisation and enhanced proactive self-management support.
“And we anticipate that the data science approach, technology infrastructure, and wider learnings from this exemplar study will accelerate the application of AI across other long-term conditions to help address growing demands on health systems caused by increasing levels of multi-morbidity.”
The AI study builds on a previous collaboration between Lenus Health and NHSGGC, which produced a digital service model for supported self management of COPD patients.
Patients currently using the digital COPD service at NHSGGC will have the option to consent to take part in the AI study, which has been given ethics and Medicines and Healthcare Products Regulatory Agency (MHRA) approval.