Planning permission for the development was granted by Buckinghamshire Council following an application prepared and submitted by Carter Jonas on behalf of the trust.
Earlier this year, MTX Contracts secured a £9.8m contract to deliver the two-storey therapies and outpatients building, which will include consultation rooms, a rehabilitation gym and therapy spaces.
The wider project team includes architect Gilling Dodd, alongside Cotswold Archaeology, NoiseAir Limited, Steven A. Hunt & Associates, iteriad, Evoke, Alan Johnston Partnership and Servtron.
The new building will replace an existing prefabricated therapies facility and has been designed to meet the requirements of a modern healthcare environment.
It will accommodate musculoskeletal (MSK), hand therapy and dietetics services, alongside outpatient facilities, clinical treatment areas, administrative accommodation and staff support spaces.
Stoke Mandeville Hospital is a major healthcare provider for Buckinghamshire, delivering emergency and specialist services including accident and emergency, maternity care, critical care and spinal injuries treatment.
The trust also operates Wycombe Hospital, Amersham Hospital, Buckingham Community Hospital and the Florence Nightingale Hospice.
The approval follows earlier planning consents for the site, including permission granted in November 2023 for the demolition of the existing therapies building as part of alternative development proposals.
Following changes to the trust's requirements, Carter Jonas secured a renewed demolition consent in January 2026, enabling preparatory works to progress ahead of the submission and approval of the new therapy hub application.
"The project involved careful navigation of the site's planning history to keep the programme on track," said Katherine Jones, Partner in Planning and Development at Carter Jonas.
The project forms part of wider investment across Buckinghamshire Healthcare NHS Trust's estate.
MTX is also delivering a six-storey building at Wycombe Hospital designed to enable services to move from the ageing Wycombe Tower Block.
The approval follows other recent investment at Stoke Mandeville Hospital, including the refurbishment of ophthalmology facilities to support expanded specialist eye care services.
